Botox injections combined with nerve blocks are used to treat chronic headaches, including migraines, tension headaches, and occipital neuralgia. Botox injections involve the injection of botulinum toxin into specific muscles in the head and neck to relax muscle tension and reduce headache frequency and severity. Nerve blocks involve the injection of local anesthetics or corticosteroids near specific nerves involved in headache generation to block pain signals and provide immediate relief.